Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 3/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382974 | 0.81 | NR3C1 (0.53) | NR3C1PGRTAS2R14PTGESKEAP1 | |
| SCHEMBL1800017 | 0.75 | MMP2 (0.44) | NR3C1PTGESMMP8MMP3ALOX5 | |
| SCHEMBL1797408 | 0.74 | MMP1 (0.40) | NR3C1PTGESMMP8MMP3DAGLA | |
| SCHEMBL6757287 | 0.74 | MMP1 (0.46) | NR3C1PTGESMMP8MMP3ALOX5 | |
| SCHEMBL3875615 | 0.73 | MMP2 (0.62) | KEAP1MMP2MMP9LMNA | |
| SCHEMBL4371638 | 0.72 | PTGES (0.48) | NR3C1PTGESMMP8MMP3ALOX5 | |
| SCHEMBL4371642 | 0.72 | PTGES (0.48) | NR3C1PTGESMMP8MMP3ALOX5 | |
| SCHEMBL3868587 | 0.72 | LMNA (0.55) | PGRPTGESMMP8MMP3MMP1 | |
| SCHEMBL4380644 | 0.71 | MMP2 (0.43) | MMP8MMP3MMP1MMP2MMP9 | |
| SCHEMBL3870207 | 0.71 | MMP2 (0.61) | MMP3MMP1MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |