Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385660 | 0.90 | RAB9A (0.48) | MEN1ALDH1A1KMT2AL3MBTL1RAB9A | |
| SCHEMBL4948489 | 0.88 | HSD11B1 (0.54) | HSD11B1MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL4380168 | 0.83 | GSK3B (0.38) | GSK3B | |
| SCHEMBL4378646 | 0.83 | MEN1 (0.46) | MEN1KMT2AL3MBTL1GSK3B | |
| SCHEMBL2066088 | 0.82 | GSK3B (0.40) | ALDH1A1RAB9AGSK3B | |
| SCHEMBL4379543 | 0.81 | CYP1A2 (0.38) | MEN1KMT2AGSK3B | |
| SCHEMBL4377879 | 0.81 | MEN1 (0.45) | MEN1KMT2AL3MBTL1GSK3B | |
| SCHEMBL2065359 | 0.80 | GSK3B (0.46) | MEN1KMT2AGSK3B | |
| SCHEMBL2065745 | 0.79 | KDM4E (0.40) | ALDH1A1RAB9AGSK3B | |
| SCHEMBL2065304 | 0.79 | GSK3B (0.40) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198287-B2 | Substituted heteroaryl pyridopyrimidone derivatives | SANOFI-AVENTIS (FR) | 2012-06-12 | — | — | US | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |