Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | GRK5 | P34947 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170131 | 0.78 | NOS3 (0.46) | PLCG1KDM4EMAPK1ERBB2MAPT | |
| SCHEMBL7788094 | 0.78 | PLCG1 (0.33) | PLCG1KDM4EMAPK1CDK2MAPT | |
| SCHEMBL17570530 | 0.77 | TSHR (0.37) | PLCG1ARCDK2ERBB2MAPT | |
| SCHEMBL4385911 | 0.75 | ALDH1A1 (0.36) | PLCG1TRPA1ERBB2MAPTELANE | |
| SCHEMBL25299754 | 0.75 | NTRK1 (0.33) | PLCG1ERBB2MAPTNOS3NOS2 | |
| SCHEMBL19798237 | 0.75 | GSK3A (0.33) | PLCG1KDM4CGSK3AGSK3B | |
| SCHEMBL2671146 | 0.75 | ALDH1A1 (0.40) | PLCG1KDM4EMAPK1ERBB2MAPT | |
| SCHEMBL19774234 | 0.75 | NOS3 (0.35) | PLCG1KDM4ENOS3NOS2 | |
| SCHEMBL28371872 | 0.73 | KDM4E (0.41) | PLCG1KDM4EMAPTKDM4C | |
| SCHEMBL6649929 | 0.72 | ROCK2 (0.45) | KDM4EMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119880-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-01 | — | — | WO | disclosed |