Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874084 | 0.79 | RNASEH1 (0.55) | RNASEH1ALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL4068634 | 0.78 | MAOB (0.69) | RNASEH1MAOACES1GAAALDH1A1 | |
| Fluorene SCHEMBL27791149 | 0.78 | MAOA (0.67) | RNASEH1MAOACES1BCHESRD5A2 | |
| SCHEMBL3358267 | 0.76 | RNASEH1 (1.00) | RNASEH1MAOACES1BCHEGAA | |
| Fluorene SCHEMBL29355380 | 0.75 | MAOA (0.68) | MAOACES1BCHEPKMSRD5A2 | |
| Fluorene SCHEMBL29478468 | 0.75 | MAOA (0.68) | MAOACES1BCHEPKMSRD5A2 | |
| Fluorene SCHEMBL545861 | 0.75 | MAOA (0.68) | MAOACES1BCHEPKMSRD5A2 | |
| Fluorene SCHEMBL31388525 | 0.75 | MAOA (0.68) | MAOACES1BCHEPKMSRD5A2 | |
| Fluorene SCHEMBL8180 | 0.75 | MAOA (0.68) | MAOACES1BCHEPKMSRD5A2 | |
| SCHEMBL2142614 | 0.73 | POLB (0.56) | RNASEH1CYP2A6NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190290733-A1 | CONJUGATES OF AN IL-7 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS | 2019-09-26 | — | — | US | disclosed |
| EP-3285799-A1 | CONJUGATES OF AN IL-7 MOIETY AND AN POLYMER | Nektar Therapeutics (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016145388-A1 | CONJUGATES OF AN IL-7 MOIETY AND AN POLYMER | NEKTAR THERAPEUTICS (US) | 2016-09-15 | — | — | WO | disclosed |
| CN-101242858-B | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | NEKTAR THERAPEUTICS AL CORP | 2012-12-19 | — | — | CN | disclosed |
| EP-2099495-A2 | CONJUGATES OF A G-CSF MOIETY AND A POLYMER | Nektar Therapeutics AL, Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| CN-101257926-A | Conjugates of G-CSF moieties with polymers | NEKTAR THERAPEUTICS AL CORP (US) | 2008-09-03 | — | — | CN | disclosed |
| CN-101242858-A | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | NEKTAR THERAPEUTICS AL CORP (US) | 2008-08-13 | — | — | CN | disclosed |
| WO-2007019331-A2 | CONJUGATES OF A G-CSF MOIETY AND A POLYMER | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290733-A1 | CONJUGATES OF AN IL-7 MOIETY AND A POLYMER | IL17A, IL2, CCR7 | RNASEH1 1974/4885MAOA 4677/4885CES1 1630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.