Sugi Predict

Sugi Predict / Compounds / SCHEMBL4387642

SCHEMBL4387642

SCHEMBL4387642

COC(=O)c1ccc(N)c(F)c1C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 6/20 0.50
▸ KDM4E B2RXH2 6/20 0.50
▸ ALDH1A1 P00352 5/20 0.50
▸ HSD17B10 Q99714 3/20 0.50
▸ CFTR P13569 3/20 0.50
▸ GLA P06280 3/20 0.50
▸ MAPT P10636 2/20 0.50
▸ HPGD P15428 2/20 0.50
▸ CASP1 P29466 1/20 0.50
▸ CASP7 P55210 1/20 0.50
▸ ATM Q13315 1/20 0.50
▸ ABL1 P00519 1/20 0.49
▸ TSHR P16473 3/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ PTGER4 P35408 1/20 0.44
▸ NPC1 O15118 1/20 0.42
▸ CASP3 P42574 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ SENP8 Q96LD8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16077594 0.86 ALDH1A1 (0.54) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL13575544 0.85 ALDH1A1 (0.53) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL136404 0.83 ALDH1A1 (0.55) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL30720952 0.81 CES2 (0.50) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL8217125 0.81 CES2 (0.50) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL2426826 0.81 PTGER4 (0.54) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL23537740 0.81 ABL1 (0.56) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL30966098 0.80 CA1 (0.50) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL25475896 0.80 CA1 (0.50) GAAKDM4EALDH1A1HSD17B10CFTR
SCHEMBL9344625 0.79 KEAP1 (0.50) GAAKDM4EALDH1A1HSD17B10GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024258789-A1 MODULATORS OF CDK2 AND USES THEREOF TRIANA BIOMEDICINES, INC. (US) 2024-12-19 — — WO disclosed
CN-118791426-A (R) -glutarimide CRBN ligands and methods of use 百济神州有限公司 2024-10-18 — — CN disclosed
US-20240343681-A1 MOLECULES HAVING PESTICIDAL UTILITY AND INTERMEDIATES AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2024-10-17 — — US disclosed
US-20240246977-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHOD OF USE BEONE MEDICINES I GMBH (CH) 2024-07-25 — — US disclosed
US-20240207267-A1 (R)-Glutarimide CRBN Ligands and Methods of Use BEIGENE SWITZERLAND GMBH (CH) 2024-06-27 — — US disclosed
US-20240207267-A1 (R)-Glutarimide CRBN Ligands and Methods of Use BEIGENE SWITZERLAND GMBH (CH) 2024-06-27 — — US disclosed
US-20240207267-A1 (R)-Glutarimide CRBN Ligands and Methods of Use BEIGENE SWITZERLAND GMBH (CH) 2024-06-27 — — US disclosed
EP-4359403-A1 (R) -GLUTARIMIDE CRBN LIGANDS AND METHODS OF USE BeiGene Switzerland GmbH (CH) 2024-05-01 — — EP disclosed
CN-117616021-A (R) -glutarimide CRBN ligands and methods of use 百济神州有限公司 2024-02-27 — — CN disclosed
EP-4313939-A1 MOLECULES HAVING PESTICIDAL UTILITY AND INTERMEDIATES AND PROCESSES RELATED THERETO Corteva Agriscience LLC (US) 2024-02-07 — — EP disclosed
WO-2022143856-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE, LTD. (KY) 2022-07-07 — — WO disclosed
WO-2022143856-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE, LTD. (KY) 2022-07-07 — — WO disclosed
US-7629363-B2 antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease PFIZER INC (US) 2009-12-08 — — US disclosed
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 — — EP disclosed
US-7067540-B2 Substituted pyridinones PHARMACIA CORPORATION (US) 2006-06-27 — — US disclosed
US-20050176775-A1 Substituted pyridinones PHARMACIA CORPORATION 2005-08-11 — — US disclosed
WO-2005018557-A2 SUBSTITUTED PYRIDINONES PHARMACIA CORPORATION (US) 2005-03-03 — — WO disclosed
EP-1490064-A1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE Pharmacia Corporation (US) 2004-12-29 — — EP disclosed
US-20040058964-A1 Substituted pyridinones PHARMACIA LLC 2004-03-25 — — US disclosed
WO-2003068230-A1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORPORATION (US) 2003-08-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240343681-A1 MOLECULES HAVING PESTICIDAL UTILITY AND INTERMEDIATES AND PROCESSES RELATED THERETO ACHE, DDT, MLYCD GAA 818/4885KDM4E 1669/4885ALDH1A1 326/4885
US-20040058964-A1 Substituted pyridinones MAPK1, MAPK6, MAPK7 GAA 2281/4885KDM4E 3869/4885ALDH1A1 787/4885
US-20240207267-A1 (R)-Glutarimide CRBN Ligands and Methods of Use CRBN, CDR2, CRKL GAA 1405/4885KDM4E 1286/4885ALDH1A1 2445/4885
US-20050176775-A1 Substituted pyridinones MAPK1, MAPK6, MAP3K6 GAA 2368/4885KDM4E 3921/4885ALDH1A1 741/4885
US-20240246977-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHOD OF USE BTK, CBL, SYK GAA 2150/4885KDM4E 1040/4885ALDH1A1 4373/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.