Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.40 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.38 |
| ▸ | STK17B | O94768 | 3/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386385 | 0.90 | HDAC3 (0.51) | DYRK1ACLK4HDAC3HDAC1HDAC2 | |
| SCHEMBL4392092 | 0.89 | RPS6KB1 (0.43) | DYRK1ACLK4HDAC3HDAC1HDAC2 | |
| SCHEMBL4392079 | 0.82 | VNN1 (0.46) | HDAC3HDAC1HDAC2HDAC6NTRK1 | |
| SCHEMBL3192454 | 0.82 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6NTRK1 | |
| SCHEMBL4389712 | 0.81 | PRKCQ (0.54) | DYRK1ASTK17APRKCQ | |
| SCHEMBL4394654 | 0.80 | APP (0.49) | HDAC3HDAC1HDAC2HDAC6RPS6KB1 | |
| SCHEMBL4385162 | 0.80 | NTRK1 (0.49) | NTRK1RPS6KB1PRKCQ | |
| SCHEMBL3189750 | 0.73 | HDAC3 (0.51) | HDAC3HDAC1HDAC2HDAC6NTRK1 | |
| SCHEMBL3182040 | 0.72 | SCD (0.47) | DYRK1ACLK4HDAC3HDAC1HDAC2 | |
| SCHEMBL4385085 | 0.71 | PRKCQ (0.54) | DYRK1AHDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131844-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | CV Therapeutics Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008123891-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |