Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394654 | 0.85 | APP (0.49) | APPPRKCQRPS6KB1JAK2JAK1 | |
| SCHEMBL4392092 | 0.83 | RPS6KB1 (0.43) | NTRK1RPS6KB1PLK4 | |
| SCHEMBL3192248 | 0.81 | NTRK1 (0.48) | NTRK1APPPRKCQRPS6KB1JAK2 | |
| SCHEMBL4386385 | 0.80 | HDAC3 (0.51) | NTRK1 | |
| SCHEMBL4387694 | 0.80 | DYRK1A (0.41) | NTRK1PRKCQRPS6KB1 | |
| SCHEMBL4380044 | 0.80 | PRKCQ (0.69) | NTRK1PRKCQ | |
| SCHEMBL4392079 | 0.76 | VNN1 (0.46) | NTRK1APPPRKCQ | |
| SCHEMBL26429360 | 0.74 | APP (0.54) | NTRK1APPPRKCQCCNT1RPS6KB1 | |
| SCHEMBL22191429 | 0.73 | GAA (0.52) | NTRK1APPPRKCQCCNT1RPS6KB1 | |
| SCHEMBL25934296 | 0.72 | GAA (0.51) | NTRK1APPPRKCQCCNT1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131844-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | CV Therapeutics Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008123891-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |