Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389645 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1TDO2GFERSPR | |
| SCHEMBL4388059 | 0.79 | PTGS2 (0.34) | PTGS2SPRSLC6A2HTR2A | |
| SCHEMBL736552 | 0.70 | IDO1 (0.47) | TDO2IDO1SLC6A2HTR2A | |
| SCHEMBL4392323 | 0.70 | MPO (0.57) | IDO1HTR2A | |
| SCHEMBL4387868 | 0.68 | HTR2A (0.55) | GFERIDO1MEN1KMT2ASLC6A2 | |
| SCHEMBL757235 | 0.68 | IDO1 (0.52) | TDO2GFERIDO1SLC6A2HTR2A | |
| SCHEMBL4963437 | 0.67 | GFER (0.57) | GFERIDO1MEN1KMT2ASLC6A2 | |
| SCHEMBL735716 | 0.66 | HTR2A (0.62) | GFERIDO1KMT2ASLC6A2HTR2A | |
| SCHEMBL4383376 | 0.66 | HTR1A (0.52) | GFERIDO1ALOX12MEN1KMT2A | |
| SCHEMBL3190980 | 0.66 | HTR2A (0.51) | GFERIDO1MEN1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629473-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2009-12-08 | — | — | US | disclosed |
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | CYP11B2, CYP1A2, CYP4B1 | PTGS2 1170/4885PTGS1 2394/4885TDO2 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.