Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | STAT1 | P42224 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709679 | 0.92 | PRMT5 (0.64) | PRMT5WDR77PDE4BALDH1A1POLB | |
| SCHEMBL8922008 | 0.84 | CHRM4 (0.59) | PRMT5WDR77ALDH1A1POLBRAB9A | |
| SCHEMBL313776 | 0.84 | PRMT5 (0.64) | PRMT5WDR77ALDH1A1POLBRAB9A | |
| SCHEMBL21138877 | 0.83 | ALDH1A1 (0.57) | PRMT5WDR77ALDH1A1POLBRAB9A | |
| SCHEMBL19493611 | 0.81 | RAB9A (0.62) | PDE4BALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL12791451 | 0.81 | RAB9A (0.62) | PDE4BALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL2025839 | 0.80 | PDE4B (0.53) | PRMT5WDR77PDE4BALDH1A1POLB | |
| SCHEMBL21159622 | 0.80 | BRD4 (0.61) | ALDH1A1SMN1; SMN2MAPTLMNACHRM4 | |
| SCHEMBL12282136 | 0.79 | ALDH1A1 (0.68) | PDE4BALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL2135668 | 0.79 | ALDH1A1 (0.68) | PDE4BALDH1A1POLBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110621675-B | Tricyclic compounds useful for the treatment of proliferative diseases | 阿古诺治疗有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-110650950-B | Compounds for the treatment or prophylaxis of PRMT5 mediated diseases | 阿古诺治疗有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-110621675-B | Tricyclic compounds useful for the treatment of proliferative diseases | 阿古诺治疗有限公司 | 2023-09-19 | — | — | CN | disclosed |
| US-11485731-B2 | Compounds and methods useful in the treatment of a PRMT5-mediated disorder | Argonaut Therapeutics Limited (GB) | 2022-11-01 | — | — | US | disclosed |
| CN-110650950-A | Compounds for treating or preventing PRMT5 mediated diseases | 阿古诺治疗有限公司 | 2020-01-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11485731-B2 | Compounds and methods useful in the treatment of a PRMT5-mediated disorder | PRMT5, PRMT6, PRMT1 | PRMT5 1/4885WDR77 143/4885PDE4B 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.