Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629186 | 0.75 | NPC1 (0.50) | RAB9AALDH1A1NPC1TDP1L3MBTL1 | |
| SCHEMBL18912013 | 0.70 | RAB9A (0.51) | RAB9AP2RX7ALDH1A1NPC1TDP1 | |
| SCHEMBL8629217 | 0.70 | ALDH1A1 (0.47) | RAB9AALDH1A1NPC1USP2L3MBTL1 | |
| SCHEMBL4398572 | 0.69 | P2RX7 (0.41) | RAB9AP2RX7ALDH1A1NPC1TDP1 | |
| SCHEMBL11126232 | 0.68 | CYP1A2 (0.40) | RAB9AP2RX7ALDH1A1NPC1TDP1 | |
| SCHEMBL4701736 | 0.68 | RAB9A (0.49) | RAB9AP2RX7ALDH1A1NPC1TDP1 | |
| SCHEMBL9007472 | 0.67 | CYP1A2 (0.39) | RAB9AP2RX7ALDH1A1NPC1TDP1 | |
| SCHEMBL29598957 | 0.66 | NISCH (0.50) | RAB9AP2RX7ALDH1A1NPC1KDM4E | |
| SCHEMBL29454745 | 0.66 | NISCH (0.50) | RAB9AP2RX7ALDH1A1NPC1KDM4E | |
| SCHEMBL78566 | 0.66 | NISCH (0.50) | RAB9AP2RX7ALDH1A1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778684-B1 | 4-PIPERAZINYL-PYRIMIDINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D<sb>3</sb> RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2009-12-16 | — | — | EP | disclosed |