Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953302 | 0.92 | L3MBTL1 (0.53) | KDM4EL3MBTL1GSK3BUGCG | |
| SCHEMBL4388471 | 0.89 | KDM4E (0.47) | KDM4EL3MBTL1POLBRAB9AALDH1A1 | |
| SCHEMBL4378646 | 0.87 | MEN1 (0.46) | L3MBTL1CYP1A2CYP2D6GSK3B | |
| SCHEMBL4377879 | 0.85 | MEN1 (0.45) | L3MBTL1CYP1A2CYP2D6GSK3B | |
| SCHEMBL4380168 | 0.83 | GSK3B (0.38) | CYP1A2CYP2D6GSK3B | |
| SCHEMBL4385219 | 0.82 | MEN1 (0.43) | L3MBTL1CYP1A2CYP2D6GSK3B | |
| SCHEMBL4387186 | 0.81 | L3MBTL1 (0.56) | KDM4EL3MBTL1UGCG | |
| SCHEMBL2066088 | 0.81 | GSK3B (0.40) | KDM4ERAB9AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL2064592 | 0.81 | F10 (0.44) | RAB9ACYP1A2CYP2D6GSK3B | |
| SCHEMBL2065310 | 0.81 | DRD2 (0.43) | RAB9ACYP1A2CYP2D6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |