Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440416 | 0.79 | CDK8 (0.33) | CDK8GSK3AGSK3BCDK9CDK5 | |
| SCHEMBL31328707 | 0.76 | GAA (0.32) | MAP4K4MINK1TNIKKMT2AHTT | |
| SCHEMBL435823 | 0.75 | PARP1 (0.41) | TET2ALOX5APFEN1KMT2AMEN1 | |
| SCHEMBL438931 | 0.73 | HAVCR2 (0.49) | CDK8GSK3AGSK3BCDK9CDK5 | |
| SCHEMBL439299 | 0.71 | BCHE (0.34) | KMT2AHTTCA1CA2CA9 | |
| SCHEMBL439853 | 0.71 | BCHE (0.43) | CDK8MAP4K4 | |
| SCHEMBL437507 | 0.71 | MAP4K4 (0.35) | TET2MAP4K4MINK1TNIKALOX5AP | |
| SCHEMBL3254363 | 0.70 | CDK8 (0.43) | CDK8GSK3AGSK3BCDK9CDK5 | |
| SCHEMBL438361 | 0.69 | ALDH1A1 (0.36) | DYRK1AKMT2AHTTALDH1A1MAPT | |
| SCHEMBL31178976 | 0.69 | CA1 (0.32) | TET2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |