Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439456 | 0.79 | CDK8 (0.33) | CDK8GSK3AGSK3BCDK9CDK5 | |
| SCHEMBL441422 | 0.75 | HAVCR2 (0.46) | CDK9HAVCR2 | |
| SCHEMBL438931 | 0.73 | HAVCR2 (0.49) | CDK8GSK3AGSK3BCDK9CDK5 | |
| SCHEMBL440869 | 0.72 | BCHE (0.46) | HAVCR2ALDH1A1MAPT | |
| SCHEMBL437520 | 0.71 | AAK1 (0.34) | — | |
| SCHEMBL442157 | 0.71 | HAVCR2 (0.36) | HAVCR2ALOX5APFEN1 | |
| SCHEMBL439645 | 0.71 | ACHE (0.46) | — | |
| 4-Chloro-6,8-Difluoroquinoline SCHEMBL30225421 | 0.70 | CDK8 (0.43) | CDK8GSK3AGSK3BCDK9CDK5 | |
| 4-Chloro-6,8-Difluoroquinoline SCHEMBL264453 | 0.70 | CDK8 (0.43) | CDK8GSK3AGSK3BCDK9CDK5 | |
| SCHEMBL441217 | 0.69 | KDM4E (0.36) | HAVCR2ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |