SCHEMBL4394692

SCHEMBL4394692

CN(C)CCCC(NC(=O)Nc1ccc(F)c(F)c1)c1ccc(C(=O)O)cc1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.52
MCHR1 Q99705 1/20 0.44
MEN1 O00255 1/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ROCK2 O75116 1/20 0.43
ROCK1 Q13464 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4400931 0.85 UTS2R (0.49) UTS2RMCHR1MEN1LMNAMAPT
SCHEMBL2476829 0.84 UTS2R (0.49) UTS2RMEN1LMNAMAPTKMT2A
SCHEMBL1482534 0.76 UTS2R (0.53) UTS2RMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL3230138 0.76 UTS2R (0.47) UTS2R
SCHEMBL3830929 0.74 UTS2R (0.51) UTS2RMEN1LMNAKMT2A
SCHEMBL2473252 0.74 HDAC1 (0.47) UTS2RMEN1LMNAMAPTKMT2A
SCHEMBL2474013 0.72 ROCK2 (0.51) MEN1KMT2ASMN1; SMN2ROCK2ROCK1
SCHEMBL3829596 0.72 UTS2R (0.47) UTS2R
SCHEMBL2474402 0.71 UTS2R (0.47) UTS2R
SCHEMBL2474114 0.71 UTS2R (0.54) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076332-B2 N- (2-aminophenyl) benzamide derivative having urea structure SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-12-13 US disclosed
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO., LTD. (JP) 2009-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE UACA, SLC14A1, ARG2 UTS2R 11/4885MCHR1 2116/4885MEN1 4006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.