SCHEMBL4400931

SCHEMBL4400931

CN(C)CCCC(NC(=O)Nc1ccc(F)c(F)c1)c1ccc(C(=O)OCc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 14/20 0.49
KMT2A Q03164 2/20 0.43
RAB9A P51151 2/20 0.43
GAA P10253 1/20 0.43
ROCK2 O75116 1/20 0.43
ROCK1 Q13464 1/20 0.43
MCHR1 Q99705 1/20 0.42
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4394692 0.85 UTS2R (0.52) UTS2RKMT2AROCK2ROCK1MCHR1
SCHEMBL3836369 0.81 UTS2R (0.46) UTS2RKMT2ARAB9AGAAMAPT
SCHEMBL1482679 0.80 UTS2R (0.50) UTS2RKMT2ARAB9AGAAROCK2
SCHEMBL2476829 0.80 UTS2R (0.49) UTS2RKMT2AMAPTMEN1LMNA
SCHEMBL4393234 0.78 UTS2R (0.47) UTS2RKMT2ARAB9AGAAMAPT
SCHEMBL3835157 0.78 GAA (0.51) KMT2ARAB9AGAAROCK2ROCK1
SCHEMBL2473029 0.73 HDAC1 (0.49) UTS2RKMT2ARAB9AMEN1
SCHEMBL4398243 0.73 ALDH1A1 (0.55) UTS2RKMT2ARAB9AGAAMAPT
SCHEMBL3832836 0.73 RAB9A (0.47) KMT2ARAB9AGAAROCK2MEN1
SCHEMBL3230138 0.72 UTS2R (0.47) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076332-B2 N- (2-aminophenyl) benzamide derivative having urea structure SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-12-13 US disclosed
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO., LTD. (JP) 2009-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE UACA, SLC14A1, ARG2 UTS2R 11/4885KMT2A 1888/4885RAB9A 1942/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.