Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KLRK1 | P26718 | 5/20 | 0.41 |
| ▸ | MICA | Q29983 | 5/20 | 0.41 |
| ▸ | RAET1L | Q5VY80 | 5/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21571478 | 0.85 | NPC1 (0.60) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL22048232 | 0.85 | NPC1 (0.50) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL18705673 | 0.85 | NPC1 (0.50) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL18705566 | 0.84 | NPC1 (0.49) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL3759581 | 0.83 | POLB (0.59) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL29100737 | 0.82 | NPC1 (0.53) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL30620180 | 0.82 | NPC1 (0.53) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL5106559 | 0.82 | NPC1 (0.53) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL15244373 | 0.82 | NPC1 (0.62) | NPC1POLBALDH1A1MAPTNTRK1 | |
| SCHEMBL3770167 | 0.82 | ALDH1A1 (0.51) | NPC1POLBALDH1A1MAPTNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629348-B2 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | MERIAL LIMITED (US) | 2009-12-08 | — | — | US | disclosed |
| US-20080139627-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | BECKMANN MARION | 2008-06-12 | — | — | US | disclosed |
| US-20080097099-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | BECKMANN MARION | 2008-04-24 | — | — | US | disclosed |
| EP-1432313-B1 | N-THIO-NICOTINAMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE AS PESTICIDES | MERIAL LTD (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7235571-B2 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | MERIAL LIMITED (US) | 2007-06-26 | — | — | US | disclosed |
| US-20040192712-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | MERIAL LIMITED | 2004-09-30 | — | — | US | disclosed |
| US-20030119852-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions, comprising them and their use as pesticides | BAYER CROPSCIENCE GMBH (GE) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139627-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | ACHE, DDT, PIR | NPC1 4481/4885POLB 4499/4885ALDH1A1 1482/4885 |
| US-20040192712-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | ACHE, DDT, PIR | NPC1 3901/4885POLB 4539/4885ALDH1A1 517/4885 |
| US-20030119852-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions, comprising them and their use as pesticides | ACHE, DDT, PIR | NPC1 4068/4885POLB 4414/4885ALDH1A1 504/4885 |
| US-20080097099-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | ACHE, DDT, PIR | NPC1 4551/4885POLB 4317/4885ALDH1A1 1101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.