Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | KLRK1 | P26718 | 8/20 | 0.38 |
| ▸ | MICA | Q29983 | 8/20 | 0.38 |
| ▸ | RAET1L | Q5VY80 | 8/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394775 | 0.85 | NPC1 (0.56) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL28163757 | 0.81 | POLB (0.54) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL22048232 | 0.79 | NPC1 (0.50) | NPC1POLBALDH1A1NTRK1MAPT | |
| Flonicamid SCHEMBL29359080 | 0.78 | ALDH1A1 (0.53) | NPC1POLBALDH1A1NTRK1MAPT | |
| Flonicamid SCHEMBL26954 | 0.78 | ALDH1A1 (0.53) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL18705566 | 0.78 | NPC1 (0.49) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL3759581 | 0.77 | POLB (0.59) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL21571478 | 0.77 | NPC1 (0.60) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL29100737 | 0.77 | NPC1 (0.53) | NPC1POLBALDH1A1NTRK1MAPT | |
| SCHEMBL5106559 | 0.77 | NPC1 (0.53) | NPC1POLBALDH1A1NTRK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3659438-A1 | COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2020-06-03 | — | — | EP | disclosed |
| US-20190350203-A1 | COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-11-21 | — | — | US | disclosed |
| US-20170094972-A1 | Compounds and Compositions Having Knock-Down Activity Against Insect Pests | SYNGENTA PARTICIPATIONS AG (CH) | 2017-04-06 | — | — | US | disclosed |
| US-20170094972-A1 | Compounds and Compositions Having Knock-Down Activity Against Insect Pests | SYNGENTA PARTICIPATIONS AG (CH) | 2017-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170094972-A1 | Compounds and Compositions Having Knock-Down Activity Against Insect Pests | DDT, AGO2, L3MBTL4 | NPC1 1539/4885POLB 4237/4885ALDH1A1 3329/4885 |
| US-20190350203-A1 | COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS | KISS1R, VIP, KDM4E | NPC1 1823/4885POLB 4505/4885ALDH1A1 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.