SCHEMBL4396402

SCHEMBL4396402

COc1ccc2occ(COc3cccc4[nH]c(OC(=O)NC5CCN(CCN6CCCCCC6)CC5)cc34)c2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.44
MCHR1 Q99705 2/20 0.39
MAOA P21397 1/20 0.39
MTNR1A P48039 2/20 0.38
MTNR1B P49286 2/20 0.38
TSHR P16473 1/20 0.38
ACHE P22303 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
DRD2 P14416 1/20 0.37
DRD3 P35462 1/20 0.37
AVPR1B P47901 1/20 0.36
CNR1 P21554 1/20 0.36
CNR2 P34972 1/20 0.36
SOS1 Q07889 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4409300 0.94 MAOB (0.44) MAOBMCHR1MAOAMTNR1AMTNR1B
SCHEMBL4403829 0.94 MAOB (0.44) MAOBMCHR1ACHEDRD2DRD3
SCHEMBL4396426 0.90 BDKRB1 (0.37) MAOBMAOADRD2DRD3SOS1
SCHEMBL4401840 0.89 MAOB (0.44) MAOBMCHR1SIGMAR1DRD2DRD3
SCHEMBL914531 0.89 MAOB (0.47) MAOBMAOAMTNR1AMTNR1BTSHR
SCHEMBL4406823 0.88 HTR4 (0.38) MCHR1MTNR1AMTNR1BDRD2DRD3
Hydrochloric Acid SCHEMBL4405534 0.84 SOS1 (0.38) MAOBMCHR1MAOASIGMAR1DRD2
SCHEMBL4405864 0.84 SOS1 (0.38) MAOBMAOADRD2DRD3SOS1
SCHEMBL4405632 0.84 MAOB (0.38) MAOBMAOADRD2DRD3
SCHEMBL4398599 0.84 ALDH1A1 (0.34) MAOBMCHR1MAOASOS1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720859-B1 CHEMOKINE RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2009-12-23 EP claimed