Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436747 | 0.86 | CYP3A4 (0.32) | DYRK1ACDC7EEF2KPLK4AURKA | |
| SCHEMBL438319 | 0.82 | NQO2 (0.36) | DYRK1A | |
| SCHEMBL436999 | 0.82 | NQO2 (0.36) | DYRK1A | |
| SCHEMBL437555 | 0.82 | HAVCR2 (0.38) | DYRK1AHAVCR2SMN1; SMN2NR4A2 | |
| SCHEMBL441951 | 0.74 | HAVCR2 (0.58) | DYRK1AHAVCR2AURKADAPK3PRKD3 | |
| SCHEMBL439423 | 0.74 | HAVCR2 (0.36) | HAVCR2SMN1; SMN2 | |
| SCHEMBL440068 | 0.72 | HAVCR2 (0.63) | HAVCR2SMN1; SMN2 | |
| SCHEMBL440009 | 0.72 | HAVCR2 (0.38) | HAVCR2 | |
| SCHEMBL439003 | 0.69 | TET2 (0.34) | DYRK1AMAP4K4EPHB4 | |
| SCHEMBL436403 | 0.69 | POLB (0.38) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |