Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441707 | 0.83 | HAVCR2 (0.63) | HAVCR2NR4A2ACHEAURKADAPK3 | |
| SCHEMBL442133 | 0.83 | BACE1 (0.41) | HAVCR2NR4A2FGFR1GSK3BCDK5 | |
| SCHEMBL441701 | 0.79 | ALDH1A1 (0.43) | HAVCR2PARP1CYP1A2CYP2A6LMNA | |
| SCHEMBL435823 | 0.79 | PARP1 (0.41) | HAVCR2PARP1CYP1A2ALDH1A1MEN1 | |
| SCHEMBL439423 | 0.79 | HAVCR2 (0.36) | HAVCR2LMNAALDH1A1MEN1MAPT | |
| SCHEMBL437767 | 0.79 | HAVCR2 (0.46) | HAVCR2NR4A2ACHECHEK1FLT3 | |
| SCHEMBL440009 | 0.76 | HAVCR2 (0.38) | HAVCR2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL438876 | 0.75 | BCHE (0.43) | HAVCR2ACHEDYRK1AALDH1A1MAPT | |
| SCHEMBL440370 | 0.75 | PARP1 (0.45) | PRKD3MAP4K4PARP1CLK2GSK3A | |
| SCHEMBL435849 | 0.75 | HTR1A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |