Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25606892 | 0.80 | HTR1A (0.44) | KDM4EALDH1A1MAPTSMN1; SMN2MAPKAPK2 | |
| SCHEMBL28476218 | 0.79 | ALDH1A1 (0.37) | KDM4EMEN1ALDH1A1POLBKMT2A | |
| SCHEMBL16156593 | 0.79 | NR4A2 (0.47) | ALDH1A1KMT2ASMN1; SMN2HPGDMAPKAPK2 | |
| SCHEMBL16156637 | 0.79 | LPL (0.41) | EGFRGAK | |
| SCHEMBL29924048 | 0.79 | LPL (0.41) | EGFRGAK | |
| SCHEMBL23911086 | 0.77 | LMNA (0.48) | KDM4EMAPTGAK | |
| SCHEMBL2512339 | 0.76 | GAK (0.41) | MAPKAPK2GAK | |
| SCHEMBL25606843 | 0.76 | EGFR (0.34) | EGFR | |
| SCHEMBL30074594 | 0.76 | EGFR (0.34) | EGFR | |
| SCHEMBL476912 | 0.75 | NCF1 (0.42) | KDM4EMEN1ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306074-A1 | THIAZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-12-10 | — | — | US | disclosed |
| EP-2004189-A2 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | DARCY MICHAEL GERARD | 2008-10-16 | — | — | US | disclosed |
| WO-2007136940-A2 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KA, JAK3, PIK3CD | KDM4E 4181/4885MEN1 3894/4885ALDH1A1 636/4885 |
| US-20090306074-A1 | THIAZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS | JAK3, DPP3, ADRB3 | KDM4E 4486/4885MEN1 2866/4885ALDH1A1 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.