Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.41 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385761 | 0.89 | CXCR2 (0.40) | — | |
| SCHEMBL4389539 | 0.84 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2L3MBTL1HPGDTDP1 | |
| SCHEMBL3104128 | 0.84 | ALDH1A1 (0.40) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL4398088 | 0.83 | TERT (0.39) | NPC1RAB9ASMN1; SMN2KDM4EMETAP2 | |
| SCHEMBL4393093 | 0.80 | NTRK1 (0.34) | — | |
| SCHEMBL5281859 | 0.79 | MEN1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL4386341 | 0.77 | SLC6A2 (0.34) | SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL20855351 | 0.75 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2HPGDTSHR | |
| SCHEMBL20870955 | 0.75 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL4398072 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799657-B1 | ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-7465805-B2 | Isoxazoline derivatives and their use as herbicides | SYNGENTA LIMITED (GB) | 2008-12-16 | — | — | US | disclosed |
| US-20080051287-A1 | Isoxazoline Derivatives and Their Use as Herbicides | SYNGENTA CROP PROTECTION, INC. (US) | 2008-02-28 | — | — | US | disclosed |
| EP-1799657-A1 | ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES | Syngenta Limited (GB) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006037945-A1 | ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051287-A1 | Isoxazoline Derivatives and Their Use as Herbicides | CYP4X1, CYP3A7, CYP4Z1 | NPC1 4321/4885RAB9A 3117/4885SMN1; SMN2 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.