Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 3/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404545 | 0.92 | MAOB (0.39) | MAOBMCHR1KCNH2ALDH1A1LTA4H | |
| SCHEMBL4400742 | 0.92 | MCHR1 (0.36) | MAOBMCHR1KCNH2SLC2A1HTR1A | |
| Hydrochloric Acid SCHEMBL4403801 | 0.92 | HTR1A (0.37) | MCHR1KCNH2HTR1A | |
| SCHEMBL4401792 | 0.92 | DRD2 (0.35) | MAOBHTR1AACHESLC6A4 | |
| SCHEMBL4401840 | 0.92 | MAOB (0.44) | MAOBMCHR1ALDH1A1LTA4HHTR1A | |
| Hydrochloric Acid SCHEMBL4396448 | 0.91 | SOS1 (0.33) | MAOBMCHR1KCNH2LTA4HHTR1A | |
| Hydrochloric Acid SCHEMBL4396591 | 0.90 | HTR1A (0.34) | MCHR1ALDH1A1HTR1ASLC6A4 | |
| SCHEMBL914491 | 0.90 | MAOB (0.43) | MAOBMCHR1KCNH2ALDH1A1LTA4H | |
| Hydrochloric Acid SCHEMBL4405664 | 0.89 | HTR1A (0.35) | MCHR1SLC2A1HTR1AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL4396450 | 0.88 | SOS1 (0.36) | MAOBMCHR1KCNH2HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |