Cystine

Cystine

SCHEMBL440078

N[C@@H](CSSC[C@H](N)C(=O)O)C(=O)O.O=C1CN(c2ccccc2)C(=O)N1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
DDB1 Q16531 1/20 0.43
CRBN Q96SW2 1/20 0.43
KIF11 P52732 15/20 0.39
DNMT1 P26358 1/20 0.36
ALPI P09923 1/20 0.36
PKM P14618 1/20 0.36
PTGS1 P23219 1/20 0.36
XIAP P98170 1/20 0.36
SLC7A5 Q01650 1/20 0.36
IDO1 P14902 1/20 0.36
TDO2 P48775 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cysteine SCHEMBL9128024 0.85 DDB1 (0.44) KDM4EGAAMAPTTDP1DDB1
SCHEMBL9130374 0.80 HTT (0.40) DDB1CRBNPKM
SCHEMBL746783 0.78 CRBN (0.66) KDM4EGAAMAPTTDP1DDB1
SCHEMBL11849406 0.76 CRBN (0.63) KDM4EGAAMAPTTDP1DDB1
Hydrochloric Acid SCHEMBL31439105 0.76 CRBN (0.63) KDM4EGAAMAPTTDP1DDB1
Cystine SCHEMBL27694930 0.71 KIF11 (0.61) KIF11DNMT1ALPIPKMPTGS1
Alanine SCHEMBL6904189 0.70 GAA (0.45) KDM4EGAAMAPTTDP1DDB1
Benzil SCHEMBL6523597 0.69 CES2 (0.52) KIF11DNMT1ALPIPKMPTGS1
Cystine SCHEMBL28236509 0.69 GSK3A (0.41) KIF11DNMT1
Cystine SCHEMBL27941984 0.69 KIF11 (0.56) KIF11ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144613-B2 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC (US) 2020-05-06 EP disclosed
US-20170362626-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. 2017-12-21 US disclosed
US-20160244798-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. 2016-08-25 US disclosed
EP-2305804-B1 MonoPEGylated human growth hormone BOLDER BIOTECHNOLOGY INC (US) 2015-05-06 EP disclosed
US-8957023-B2 Methods for making proteins containing free cysteine residues BOLDER BIOTECHNOLOGY INC. (US) 2015-02-17 US disclosed
US-8932828-B2 Method for preparing recombinant granulocyte colony stimulating factor cysteine muteins BOLDER BIOTECHNOLOGY, INC. (US) 2015-01-13 US disclosed
US-20130217629-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. (US) 2013-08-22 US disclosed
US-8288126-B2 Methods for making proteins containing free cysteine residues BOLDER BIOTECHNOLOGY, INC. (US) 2012-10-16 US disclosed
US-20120064573-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-03-15 US disclosed
EP-1144613-B1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC (US) 2011-09-28 EP disclosed
US-7306931-B2 Lysis, denaturing, reducing Growth hormones BOLDER BIOTECHNOLOGY, INC. (US) 2007-12-11 US disclosed
EP-1284987-B1 METHODS FOR REFOLDING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC (US) 2007-07-18 EP disclosed
US-20050187160-A1 Monopegylated growth hormone proteins BOLDER BIOTECHNOLOGY INC. (US) 2005-08-25 US disclosed
US-6753165-B1 FOR RESIDUES THAT DO NOT FORM DISULFIDE BOND BOLDER BIOTECHNOLOGY, INC. 2004-06-22 US disclosed
US-20040018586-A1 Lysis, denaturing, reducing Growth hormones NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-01-29 US disclosed
EP-1284987-A2 METHODS FOR REFOLDING PROTEINS CONTAINING FREE CYSTEINE RESIDUES Bolder Biotechnology, Inc. (US) 2003-02-26 EP disclosed
EP-1144613-A4 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC (US) 2002-10-29 EP disclosed
WO-2001087925-A2 METHODS FOR REFOLDING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. (US) 2001-11-22 WO disclosed
EP-1144613-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES Bolder Biotechnology, Inc. (US) 2001-10-17 EP disclosed
WO-2000042175-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC. (US) 2000-07-20 WO disclosed