Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PTPRA | P18433 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357437 | 0.84 | HTT (0.53) | HTTMAPK1ALDH1A1TP53PKM | |
| Cystine SCHEMBL440078 | 0.80 | KDM4E (0.43) | PKMDDB1CRBN | |
| SCHEMBL9130369 | 0.77 | ALDH1A1 (0.40) | HTTMAPK1ALDH1A1TP53PKM | |
| Cysteine SCHEMBL9128024 | 0.74 | DDB1 (0.44) | PKMDDB1CRBN | |
| SCHEMBL11197175 | 0.71 | CYP1A2 (0.55) | MAPK1ALDH1A1PKMLMNAPTPRA | |
| SCHEMBL11197173 | 0.71 | CYP1A2 (0.55) | MAPK1ALDH1A1PKMLMNAPTPRA | |
| SCHEMBL30428132 | 0.67 | SLC1A5 (0.56) | ALDH1A1PTPRASMN1; SMN2 | |
| SCHEMBL1768948 | 0.67 | SLC1A5 (0.56) | ALDH1A1PTPRASMN1; SMN2 | |
| SCHEMBL1176394 | 0.67 | SLC1A5 (0.56) | ALDH1A1PTPRASMN1; SMN2 | |
| SCHEMBL7320616 | 0.67 | KIF11 (0.57) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387673-A | Consisting of amino acids 70 to 155 of basic fibroblast growth factor; binds to heparin or heparin sepharose | AMERICAN CYANAMID COMPANY (US) | 1995-02-07 | — | — | US | disclosed |
| US-5206354-A | Shortest fragment that retains biological activity | AMERICAN CYANAMID COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0486861-A1 | Active fragments of fibroblast growth factor | AMERICAN CYANAMID COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |