Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 9/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.66 |
| ▸ | TSPO | P30536 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14839390 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL14304865 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL15616860 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL12877443 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL15186127 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL15926494 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL12880046 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13841831 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL14278853 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL9889327 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897588-B1 | AN INHALABLE MEDICAMENT | TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D INC (US) | 2019-07-17 | — | — | EP | disclosed |
| EP-2897589-B1 | AN INHALABLE MEDICAMENT | TEVA BRANDED PHARMACEUTICAL PROD R & D INC (US) | 2018-01-03 | — | — | EP | disclosed |
| EP-2552912-B1 | SYNTHESIS METHOD FOR PRODUCING TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2017-08-02 | — | — | EP | disclosed |
| US-9707295-B2 | Inhalable medicament | TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9655969-B2 | Inhalable medicament comprising tiotropium | TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| EP-3143998-A1 | AN INHALABLE MEDICAMENT COMPRISING TIOTROPIUM | Teva Branded Pharmaceutical Products R & D, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |
| US-20160279356-A1 | INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC | BOEHRINGER INGELHEIM PHARMA (DE) | 2016-09-29 | — | — | US | disclosed |
| US-9440945-B2 | Methods for the synthesis of tiotropium bromide | BILGIC MAHMUT (TR) | 2016-09-13 | — | — | US | disclosed |
| US-9440945-B2 | Methods for the synthesis of tiotropium bromide | BILGIC MAHMUT (TR) | 2016-09-13 | — | — | US | disclosed |
| US-20160250197-A1 | AN INHALABLE MEDICAMENT | TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. (US) | 2016-09-01 | — | — | US | disclosed |
| US-20100105913-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | SICOR, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105913-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | SICOR, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100099867-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | SICOR, INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099867-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | SICOR, INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-7662963-B2 | Process for the preparation of tiotropium bromide | SICOR INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090247747-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | SICOR, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090062325-A1 | DEUTERIUM-ENRICHED TIOTROPIUM | PROTIA, LLC (US) | 2009-03-05 | — | — | US | disclosed |
| US-20090062325-A1 | DEUTERIUM-ENRICHED TIOTROPIUM | PROTIA, LLC (US) | 2009-03-05 | — | — | US | disclosed |
| US-20080051582-A1 | Process for the preparation of tiotropium bromide | SICOR INC. (US) | 2008-02-28 | — | — | US | disclosed |
| US-20070167480-A1 | Pure and stable tiotropium bromide | SICOR INC. (US) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062325-A1 | DEUTERIUM-ENRICHED TIOTROPIUM | MC2R, NR3C2, HSD11B2 | CHRM3 76/4885CHRM2 346/4885CHRM1 511/4885 |
| US-20160279356-A1 | INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC | TTK, CHRM4, DEK | CHRM3 9/4885CHRM2 10/4885CHRM1 36/4885 |
| US-20080051582-A1 | Process for the preparation of tiotropium bromide | ADRA2B, ADRA1B, CYP3A5 | CHRM3 12/4885CHRM2 56/4885CHRM1 158/4885 |
| US-20090247747-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | ADRA2B, ADRA1B, CYP3A5 | CHRM3 12/4885CHRM2 56/4885CHRM1 158/4885 |
| US-20100105913-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | ADRA2B, ADRA1B, CYP3A5 | CHRM3 12/4885CHRM2 56/4885CHRM1 158/4885 |
| US-20070167480-A1 | Pure and stable tiotropium bromide | THOP1, GUCY1B2, HSD11B2 | CHRM3 69/4885CHRM2 105/4885CHRM1 535/4885 |
| US-20100099867-A1 | PROCESS FOR THE PREPARATION OF TIOTROPIUM BROMIDE | ADRA2B, ADRA1B, CYP3A5 | CHRM3 12/4885CHRM2 56/4885CHRM1 158/4885 |
| US-20160250197-A1 | AN INHALABLE MEDICAMENT | ORAI1, CA2, TRPM8 | CHRM3 45/4885CHRM2 156/4885CHRM1 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.