Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.86 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.65 |
| ▸ | GCGR | P47871 | 4/20 | 0.65 |
| ▸ | RAF1 | P04049 | 4/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074753 | 0.87 | MAPK13 (0.83) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL16667652 | 0.85 | MAPK13 (0.83) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| Benzene SCHEMBL28852698 | 0.85 | MAPK13 (0.82) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL104130 | 0.85 | MAPK13 (0.82) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL25008485 | 0.84 | ALOX5 (0.67) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| Methane SCHEMBL3278320 | 0.83 | MAPK13 (0.79) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL27850480 | 0.83 | MAPK13 (0.79) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL252964 | 0.82 | MAPK13 (0.85) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL15401173 | 0.82 | MAPK13 (0.85) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9619859 | 0.82 | MAPK13 (0.85) | BRAFMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259875-A1 | Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof | REDPOINT BIO CORPORATION | 2007-11-08 | — | — | US | claimed |
| EP-2015638-A2 | TRIARYL SUBSTITUTED IMIDAZOLE DERIVATIVES AND TASTE-INHIBITING USES THEREOF | Redpoint Bio Corporation (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20070259875-A1 | Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof | REDPOINT BIO CORPORATION | 2007-11-08 | — | — | US | disclosed |
| US-20070259875-A1 | Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof | REDPOINT BIO CORPORATION | 2007-11-08 | — | — | US | disclosed |
| US-20070259875-A1 | Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof | REDPOINT BIO CORPORATION | 2007-11-08 | — | — | US | disclosed |
| WO-2007127479-A2 | TRIARYL SUBSTITUTED IMIDAZOLE DERIVATIVES AND TASTE-INHIBITING USES THEREOF | REDPOINT BIO CORPORATION (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259875-A1 | Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof | TAS1R3, TAS2R1, TAS1R1 | BRAF 2365/4885MAPK13 3416/4885MAPK12 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.