Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21589409 | 0.80 | MAPT (0.61) | PI4KBRAB9AALDH1A1NPC1GAA | |
| SCHEMBL4417117 | 0.77 | LMNA (0.63) | PI4KBRORCRAB9AALDH1A1NPC1 | |
| SCHEMBL838537 | 0.74 | SMN1; SMN2 (0.61) | PI4KBRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL4420194 | 0.74 | HDAC1 (0.65) | RAB9AALDH1A1NPC1GAAMAPT | |
| SCHEMBL480651 | 0.73 | KMT2A (0.69) | RAB9AALDH1A1NPC1MAPTKMT2A | |
| SCHEMBL610572 | 0.72 | RORC (0.53) | PI4KBRORCRAB9AALDH1A1NPC1 | |
| SCHEMBL1915737 | 0.72 | FFAR2 (0.45) | TYRRORCKMT2A | |
| SCHEMBL1915733 | 0.72 | FFAR2 (0.45) | TYRRORCKMT2A | |
| SCHEMBL2452315 | 0.71 | ELOVL1 (0.72) | RAB9AALDH1A1NPC1MAPTKMT2A | |
| SCHEMBL4408570 | 0.70 | GAA (0.61) | RAB9AALDH1A1NPC1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |