Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411263 | 0.93 | SLC6A3 (0.37) | CCR8ACHEFAAHMAPTKMT2A | |
| SCHEMBL4394218 | 0.92 | CCR8 (0.41) | CCR8SOS1FAAHHTR1AHTR7 | |
| SCHEMBL4404557 | 0.92 | CCR8 (0.43) | CCR8SOS1FAAHMAPTKMT2A | |
| SCHEMBL4542491 | 0.89 | HTR7 (0.37) | CCR8HTR1AHTR7 | |
| SCHEMBL6963601 | 0.88 | CCR8 (0.42) | CCR8KMT2AHTR1AHTR7 | |
| SCHEMBL914582 | 0.88 | CCR8 (0.42) | CCR8KMT2AHTR1AHTR7 | |
| SCHEMBL4400741 | 0.85 | L3MBTL1 (0.39) | CCR8SOS1FAAH | |
| SCHEMBL4403841 | 0.85 | CCR8 (0.39) | CCR8FAAH | |
| SCHEMBL4406787 | 0.85 | PARP1 (0.37) | CCR8ACHEKMT2AHTR1AHTR7 | |
| SCHEMBL4405829 | 0.85 | PARP1 (0.37) | CCR8ACHEKMT2AHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |