Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416032 | 0.76 | RAB9A (0.55) | ALOX15RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL4435799 | 0.76 | KCNQ3 (0.48) | RAB9ALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20552051 | 0.69 | PKM (0.42) | NPC1LMNAPKMALDH1A1 | |
| SCHEMBL3452770 | 0.69 | ALDH1A1 (0.54) | ALOX15LMNAMEN1POLBKMT2A | |
| SCHEMBL4297883 | 0.68 | ALOX15 (0.58) | ALOX15RAB9ANPC1FFAR2LMNA | |
| SCHEMBL966406 | 0.67 | ALOX15 (0.53) | ALOX15FFAR2LMNAMEN1KMT2A | |
| SCHEMBL27545748 | 0.67 | ALOX15 (0.53) | ALOX15RAB9ANPC1FFAR2SMN1; SMN2 | |
| SCHEMBL5837008 | 0.67 | SMN1; SMN2 (0.56) | ALOX15RAB9ANPC1FFAR2LMNA | |
| SCHEMBL5835745 | 0.67 | MAPT (0.50) | ALOX15FFAR2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5839769 | 0.67 | ALOX15 (0.49) | ALOX15RAB9ANPC1FFAR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |