Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 11/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414341 | 0.90 | USP30 (0.40) | USP30GSK3ARAF1BRAF | |
| SCHEMBL5603910 | 0.90 | USP30 (0.40) | USP30GSK3ABRAFHSP90AA1SSTR4 | |
| SCHEMBL14473259 | 0.89 | GSK3A (0.41) | USP30GSK3ARAF1BRAFHSP90AA1 | |
| SCHEMBL4413451 | 0.83 | RAF1 (0.36) | USP30RAF1BRAFMAPT | |
| SCHEMBL4420133 | 0.83 | RAB9A (0.48) | RAF1BRAF | |
| SCHEMBL4411132 | 0.83 | BRAF (0.38) | RAF1BRAFMAPT | |
| SCHEMBL4569989 | 0.83 | DRD2 (0.44) | — | |
| SCHEMBL14473174 | 0.81 | RAF1 (0.36) | RAF1BRAFMAPT | |
| SCHEMBL4408296 | 0.81 | RAF1 (0.36) | RAF1BRAFMAPT | |
| SCHEMBL4409883 | 0.80 | MAPK14 (0.36) | RAF1BRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |