Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.36 |
| ▸ | BRAF | P15056 | 13/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14473174 | 0.87 | RAF1 (0.36) | RAF1BRAFMAPTMAPK14LRRK2 | |
| SCHEMBL4408296 | 0.87 | RAF1 (0.36) | RAF1BRAFMAPTMAPK14LRRK2 | |
| SCHEMBL4417914 | 0.83 | TEK (0.43) | RAF1BRAF | |
| SCHEMBL4412696 | 0.83 | USP30 (0.40) | RAF1BRAFMAPTUSP30 | |
| SCHEMBL4411132 | 0.83 | BRAF (0.38) | RAF1BRAFMAPTMAPK14LRRK2 | |
| SCHEMBL4420133 | 0.82 | RAB9A (0.48) | RAF1BRAF | |
| SCHEMBL4414341 | 0.82 | USP30 (0.40) | RAF1BRAFMAPK14USP30 | |
| SCHEMBL4569989 | 0.80 | DRD2 (0.44) | — | |
| SCHEMBL4410028 | 0.80 | MAPT (0.38) | RAF1BRAFMAPTMAPK14LRRK2 | |
| SCHEMBL5603582 | 0.80 | MAPK14 (0.37) | RAF1BRAFMAPTMAPK14LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |