Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420133 | 0.88 | RAB9A (0.48) | KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL4414341 | 0.88 | USP30 (0.40) | RAB9A | |
| SCHEMBL4416983 | 0.86 | RAB9A (0.41) | DRD2KDM4EALDH1A1RAB9AABCG2 | |
| SCHEMBL4411132 | 0.84 | BRAF (0.38) | CYP1A2CYP3A4 | |
| SCHEMBL4412696 | 0.83 | USP30 (0.40) | — | |
| SCHEMBL4565792 | 0.80 | MAPT (0.41) | ALDH1A1CYP1A2CYP3A4RAB9A | |
| SCHEMBL4413451 | 0.80 | RAF1 (0.36) | — | |
| SCHEMBL4410129 | 0.80 | MEN1 (0.44) | KDM4EALDH1A1CYP1A2CYP3A4MAPK1 | |
| SCHEMBL4411278 | 0.80 | MAPT (0.37) | KDM4EALDH1A1CYP1A2CYP3A4RAB9A | |
| SCHEMBL4730519 | 0.79 | ABCG2 (0.45) | DRD2KDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |