Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413312 | 0.96 | LMNA (0.42) | EGFRWEE1ITKEPHX2KDM4E | |
| SCHEMBL4414542 | 0.86 | KCNH3 (0.39) | GSK3BTBK1 | |
| SCHEMBL4410707 | 0.85 | TBK1 (0.38) | EGFRFGFR1TBK1 | |
| SCHEMBL4413555 | 0.85 | BRAF (0.38) | EGFRFGFR1WEE1GSK3BTBK1 | |
| SCHEMBL4416339 | 0.84 | KDM4E (0.43) | EGFRFGFR1WEE1KDM4EALDH1A1 | |
| SCHEMBL4410855 | 0.84 | CCNT1 (0.42) | FGFR1WEE1TBK1 | |
| SCHEMBL4415084 | 0.83 | MAPK10 (0.36) | EGFRFGFR1WEE1GSK3BTBK1 | |
| SCHEMBL4412920 | 0.83 | MAPK10 (0.36) | EGFRFGFR1WEE1GSK3BTBK1 | |
| SCHEMBL4411774 | 0.83 | MAPK10 (0.36) | EGFRFGFR1ITKGSK3AGSK3B | |
| SCHEMBL4416830 | 0.83 | BRAF (0.44) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |