Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLR1A | O95602 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559621 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1SCN9ALMNAPOLR1A | |
| SCHEMBL4413312 | 0.87 | LMNA (0.42) | KDM4ELMNAEGFRPDGFRBKIT | |
| SCHEMBL4413555 | 0.85 | BRAF (0.38) | ABL1EGFRPDGFRBKITFGFR1 | |
| SCHEMBL4412966 | 0.84 | EGFR (0.41) | KDM4EALDH1A1EGFRFGFR1WEE1 | |
| SCHEMBL4415084 | 0.83 | MAPK10 (0.36) | ABL1EGFRPDGFRBKITFGFR1 | |
| SCHEMBL4412920 | 0.83 | MAPK10 (0.36) | ABL1EGFRPDGFRBKITFGFR1 | |
| SCHEMBL4414542 | 0.83 | KCNH3 (0.39) | — | |
| SCHEMBL4416830 | 0.83 | BRAF (0.44) | SCN9A | |
| SCHEMBL4411774 | 0.83 | MAPK10 (0.36) | ABL1EGFRPDGFRBKITFGFR1 | |
| SCHEMBL4418433 | 0.82 | CDK2 (0.47) | ABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |