Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412966 | 0.96 | EGFR (0.41) | EGFRWEE1EPHX2KDM4EKMT2A | |
| SCHEMBL4416339 | 0.87 | KDM4E (0.43) | LMNAPDGFRBPDGFRAEGFRWEE1 | |
| SCHEMBL4413555 | 0.86 | BRAF (0.38) | PDGFRBPDGFRAEGFRWEE1KIT | |
| SCHEMBL4415084 | 0.84 | MAPK10 (0.36) | PDGFRBPDGFRAEGFRWEE1KIT | |
| SCHEMBL4412920 | 0.84 | MAPK10 (0.36) | PDGFRBPDGFRAEGFRWEE1KIT | |
| SCHEMBL4414542 | 0.84 | KCNH3 (0.39) | FLT3MAPK10 | |
| SCHEMBL4411774 | 0.84 | MAPK10 (0.36) | PDGFRBPDGFRAAURKAAURKBEGFR | |
| SCHEMBL4416830 | 0.84 | BRAF (0.44) | AURKAAURKB | |
| SCHEMBL4410707 | 0.83 | TBK1 (0.38) | PDGFRBPDGFRAEGFRKITMAPK10 | |
| SCHEMBL4418433 | 0.83 | CDK2 (0.47) | AURKAAURKBMAPK10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |