Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412618 | 0.88 | EGFR (0.49) | EGFRMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4415797 | 0.85 | KDR (0.46) | BRAFEGFRLCKDHFRMEN1 | |
| SCHEMBL4417806 | 0.78 | SYK (0.43) | EGFRSMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL4414478 | 0.77 | PLAU (0.39) | EGFRMEN1KMT2AMAPTSYK | |
| SCHEMBL4411784 | 0.77 | MAPT (0.52) | EGFRMAPK1SMN1; SMN2DHFRKMT2A | |
| SCHEMBL4414428 | 0.75 | EGFR (0.47) | EGFRMAPK1SMN1; SMN2 | |
| SCHEMBL4417948 | 0.73 | GAA (0.43) | LCKMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4427810 | 0.73 | EGFR (0.45) | BRAFEGFRHDAC6MEN1KMT2A | |
| SCHEMBL4414311 | 0.73 | EGFR (0.53) | EGFRMEN1KMT2AMAPTSYK | |
| SCHEMBL4412315 | 0.73 | ABCG2 (0.44) | EGFRSMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |