Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595948 | 1.00 | BACE1 (0.36) | BACE1BACE2APPCTSDCHRM3 | |
| SCHEMBL4596041 | 0.88 | KDM4E (0.32) | BACE1CHRM3KDM4ENSD3SLC6A9 | |
| SCHEMBL4597510 | 0.88 | KDM4E (0.32) | BACE1CHRM3KDM4ENSD3SLC6A9 | |
| SCHEMBL4596366 | 0.84 | CHRM2 (0.37) | BACE1CHRM3CHRM2SLC6A9 | |
| SCHEMBL4596721 | 0.84 | CHRM2 (0.37) | BACE1CHRM3CHRM2SLC6A9 | |
| SCHEMBL4597467 | 0.83 | KDM4E (0.31) | KDM4ENSD3 | |
| SCHEMBL4426327 | 0.80 | SIGMAR1 (0.32) | CHRM3GRIN1GRIN2AGRIN2B | |
| SCHEMBL5179386 | 0.78 | GRIN1 (0.38) | CHRM3CHRM2GRIN1GRIN2AGRIN2B | |
| SCHEMBL4610698 | 0.78 | NSD3 (0.36) | CHRM3CHRM2KDM4ENSD3 | |
| SCHEMBL4626507 | 0.78 | NSD3 (0.36) | CHRM3CHRM2KDM4ENSD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088860-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070758-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |