Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596721 | 1.00 | CHRM2 (0.37) | CHRM2CHRM3BACE1DRD2DPP4 | |
| SCHEMBL4596506 | 0.90 | DRD2 (0.34) | BACE1DRD2DPP4DPP9DPP8 | |
| SCHEMBL4597256 | 0.90 | DRD2 (0.34) | BACE1DRD2DPP4DPP9DPP8 | |
| SCHEMBL4597579 | 0.86 | DRD2 (0.33) | DRD2DPP4DPP9DPP8HTR2C | |
| SCHEMBL4415834 | 0.84 | BACE1 (0.36) | CHRM2CHRM3BACE1SLC6A9 | |
| SCHEMBL4595948 | 0.84 | BACE1 (0.36) | CHRM2CHRM3BACE1SLC6A9 | |
| SCHEMBL4597529 | 0.77 | BACE1 (0.38) | BACE1DRD2DPP4DPP9DPP8 | |
| SCHEMBL4596625 | 0.77 | HTR2C (0.35) | CHRM2CHRM3BACE1HTR2CHTR2B | |
| SCHEMBL4598027 | 0.77 | CHRNA1 (0.32) | CHRM2CHRM3BACE1SLC6A4HTR6 | |
| SCHEMBL4597825 | 0.76 | CHRM2 (0.39) | CHRM2CHRM3DRD2DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |