Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596041 | 1.00 | KDM4E (0.32) | KDM4ENSD3OPRL1SLC6A9MEN1 | |
| SCHEMBL4595948 | 0.88 | BACE1 (0.36) | KDM4ENSD3SLC6A9CHRM3BACE1 | |
| SCHEMBL4415834 | 0.88 | BACE1 (0.36) | KDM4ENSD3SLC6A9CHRM3BACE1 | |
| SCHEMBL4598027 | 0.87 | CHRNA1 (0.32) | KDM4EOPRL1MEN1ALDH1A1MAPT | |
| SCHEMBL4596625 | 0.87 | HTR2C (0.35) | KDM4ENSD3MEN1ALDH1A1MAPT | |
| SCHEMBL4597256 | 0.87 | DRD2 (0.34) | MEN1ALDH1A1KMT2ABACE1 | |
| SCHEMBL4596506 | 0.87 | DRD2 (0.34) | MEN1ALDH1A1KMT2ABACE1 | |
| SCHEMBL4596707 | 0.84 | GABRA1 (0.32) | — | |
| SCHEMBL4597467 | 0.83 | KDM4E (0.31) | KDM4ENSD3 | |
| SCHEMBL4597523 | 0.78 | NPSR1 (0.32) | KDM4ENSD3ALDH1A1MAPTCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |