Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.63 |
| ▸ | IL1RN | P18510 | 1/20 | 0.63 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | G6PD | P11413 | 1/20 | 0.51 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2067538 | 0.87 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 | |
| SCHEMBL522424 | 0.85 | LMNA (0.72) | ALDH1A1SMN1; SMN2KEAP1MEN1KMT2A | |
| SCHEMBL13212307 | 0.80 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 | |
| SCHEMBL9345893 | 0.80 | GAA (0.69) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 | |
| SCHEMBL25031372 | 0.78 | KEAP1 (1.00) | ALDH1A1KEAP1IL1RNERAP1MEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.78 | KEAP1 (1.00) | ALDH1A1KEAP1IL1RNERAP1MEN1 | |
| SCHEMBL810795 | 0.78 | KMT2A (0.91) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 | |
| SCHEMBL13146416 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 | |
| SCHEMBL6801689 | 0.78 | RECQL (0.62) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 | |
| SCHEMBL3791578 | 0.78 | TSHR (0.74) | ALDH1A1SMN1; SMN2KEAP1IL1RNERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | disclosed |
| US-5155015-A | Containing dye which is easily decolorized or eluted during processing | FUJI PHOTO FILM CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |