Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.32 |
| ▸ | CCR5 | P51681 | 9/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027201 | 0.89 | CCR2 (0.39) | CCR2CCR5MEN1KMT2A | |
| SCHEMBL4428634 | 0.89 | TLR7 (0.32) | — | |
| SCHEMBL4426062 | 0.84 | CCR2 (0.37) | CCR2CCR5 | |
| SCHEMBL4424140 | 0.84 | IRAK4 (0.41) | CCR2 | |
| SCHEMBL4426067 | 0.83 | CNR1 (0.40) | CCR2CCR5 | |
| SCHEMBL4551359 | 0.83 | NSD2 (0.47) | — | |
| SCHEMBL4417401 | 0.83 | IRAK4 (0.39) | CCR2CCR5 | |
| SCHEMBL4418746 | 0.83 | CCR2 (0.49) | CCR2CCR5 | |
| SCHEMBL4422907 | 0.82 | PIK3CD (0.44) | MEN1KMT2A | |
| SCHEMBL4419993 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |