Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.49 |
| ▸ | CCR5 | P51681 | 12/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | CCRL2 | O00421 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417401 | 0.91 | IRAK4 (0.39) | CCR2CCR5KCNH2CHRM2CHRM4 | |
| SCHEMBL4424140 | 0.90 | IRAK4 (0.41) | CCR2IRAK4 | |
| SCHEMBL5029731 | 0.90 | CCR2 (0.59) | CCR2CCR5KCNH2CHRM2CHRM4 | |
| SCHEMBL4551359 | 0.87 | NSD2 (0.47) | IRAK4 | |
| SCHEMBL4426067 | 0.85 | CNR1 (0.40) | CCR2CCR5 | |
| SCHEMBL4421314 | 0.83 | CCR2 (0.38) | CCR2CCR5KCNH2CHRM2CHRM4 | |
| SCHEMBL4415059 | 0.83 | CCR2 (0.35) | CCR2CCR5KCNH2 | |
| SCHEMBL4417824 | 0.83 | FFAR2 (0.33) | CCR2CCR5 | |
| SCHEMBL4417546 | 0.83 | CCR2 (0.32) | CCR2CCR5 | |
| SCHEMBL4424128 | 0.82 | CCR2 (0.35) | CCR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |