Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 14/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424140 | 0.89 | IRAK4 (0.41) | IRAK4 | |
| SCHEMBL4417401 | 0.89 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL5030716 | 0.89 | NSD2 (0.46) | NSD2EGFRLRRK2KDM4ELMNA | |
| SCHEMBL4426067 | 0.89 | CNR1 (0.40) | NSD2KDM4E | |
| SCHEMBL4418746 | 0.87 | CCR2 (0.49) | IRAK4 | |
| SCHEMBL4417824 | 0.85 | FFAR2 (0.33) | — | |
| SCHEMBL4424128 | 0.84 | CCR2 (0.35) | NSD2 | |
| SCHEMBL4422907 | 0.83 | PIK3CD (0.44) | EGFRKDM4ELMNAHPGD | |
| SCHEMBL4417546 | 0.83 | CCR2 (0.32) | — | |
| SCHEMBL4426062 | 0.81 | CCR2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |