Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 15/20 | 0.39 |
| ▸ | CCR5 | P51681 | 14/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424140 | 0.92 | IRAK4 (0.41) | IRAK4CCR2CNR1 | |
| SCHEMBL4418746 | 0.91 | CCR2 (0.49) | IRAK4CCR2CCR5CHRM2CHRM4 | |
| SCHEMBL4551359 | 0.89 | NSD2 (0.47) | IRAK4 | |
| SCHEMBL5030504 | 0.89 | CCR2 (0.48) | IRAK4CCR2CCR5CNR1CNR2 | |
| SCHEMBL4426067 | 0.87 | CNR1 (0.40) | CCR2CCR5CNR1CNR2 | |
| SCHEMBL4417824 | 0.85 | FFAR2 (0.33) | CCR2CCR5 | |
| SCHEMBL4424128 | 0.84 | CCR2 (0.35) | CCR2CCR5CNR1CNR2 | |
| SCHEMBL4422907 | 0.83 | PIK3CD (0.44) | — | |
| SCHEMBL4417546 | 0.83 | CCR2 (0.32) | CCR2CCR5 | |
| SCHEMBL4421314 | 0.82 | CCR2 (0.38) | CCR2CCR5CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |