Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 16/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 12/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551359 | 0.89 | NSD2 (0.47) | NSD2KDM4E | |
| SCHEMBL5032022 | 0.89 | CCR2 (0.48) | CNR1CCR2CCR5CNR2RXFP1 | |
| SCHEMBL4424128 | 0.88 | CCR2 (0.35) | CNR1CCR2CCR5CNR2NSD2 | |
| SCHEMBL4424140 | 0.88 | IRAK4 (0.41) | CNR1CCR2 | |
| SCHEMBL4417401 | 0.87 | IRAK4 (0.39) | CNR1CCR2CCR5CNR2 | |
| SCHEMBL4416711 | 0.86 | CNR1 (0.37) | CNR1CCR2CCR5CNR2 | |
| SCHEMBL4413722 | 0.86 | F10 (0.35) | CNR1CCR2CCR5CNR2ALDH1A1 | |
| SCHEMBL4418746 | 0.85 | CCR2 (0.49) | CCR2CCR5 | |
| SCHEMBL4421724 | 0.85 | F10 (0.36) | CNR1CCR2CCR5 | |
| SCHEMBL4428598 | 0.85 | F10 (0.36) | CNR1CCR2CCR5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |