Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14755887 | 1.00 | SLC6A3 (0.38) | SLC6A3CHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL21335731 | 0.89 | CHRM2 (0.40) | SLC6A3CHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL23559739 | 0.84 | SLC6A3 (0.44) | SLC6A3TDP1 | |
| SCHEMBL21913572 | 0.84 | SLC6A3 (0.44) | SLC6A3TDP1 | |
| SCHEMBL15112779 | 0.84 | SLC6A3 (0.44) | SLC6A3TDP1 | |
| SCHEMBL4378227 | 0.79 | TDP1 (0.36) | TDP1 | |
| SCHEMBL10607812 | 0.79 | NCF1 (0.33) | SLC6A3CHRNB2CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL14598562 | 0.79 | TDP1 (0.36) | TDP1 | |
| SCHEMBL5398400 | 0.79 | TDP1 (0.36) | TDP1 | |
| SCHEMBL4378224 | 0.79 | TDP1 (0.36) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318493-A1 | Aryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-24 | — | — | US | claimed |
| US-20090318493-A1 | Aryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318493-A1 | Aryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof | TPH2, TPH1, ADRA2C | SLC6A3 44/4885CHRNB2 68/4885CHRNA7 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.