Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamide SCHEMBL4303750 | 0.88 | ACHE (0.45) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL203782 | 0.87 | ACHE (0.56) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29556815 | 0.87 | ACHE (0.56) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL28017981 | 0.85 | ACHE (0.54) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL27388788 | 0.80 | CA1 (0.48) | FFAR4ALDH1A1KDM4EGAARAPGEF4 | |
| SCHEMBL22552102 | 0.80 | ACHE (0.45) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21872115 | 0.78 | RAPGEF4 (0.46) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28340937 | 0.75 | ACHE (0.48) | ACHEFFAR4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2611542 | 0.75 | ACHE (0.65) | ACHEALDH1A1SMN1; SMN2GAACYP3A4 | |
| SCHEMBL24811430 | 0.74 | TRPV4 (0.41) | ALDH1A1SMN1; SMN2TRPV4CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635775-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |
| US-7183281-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-20060293332-A1 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. | 2006-12-28 | — | — | US | disclosed |
| US-7056937-B2 | Sulfonylquinoxalone derivatives as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1501807-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040147520-A1 | Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. | 2004-07-29 | — | — | US | disclosed |
| US-20040147519-A1 | Sulfonylquinoxalone acetamide derivatives as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. | 2004-07-29 | — | — | US | disclosed |
| WO-2003093245-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |
| US-6576613-B1 | Arginine derivatives; monitoring plasminogen activator levels; inhibiting angiogenesis and tumor cell growth | CORVAS INTERNATIONAL, INC. | 2003-06-10 | — | — | US | disclosed |
| US-6432922-B1 | ANTITUMOR AGENTS; ANGIOGENESIS INHIBITORS | CORVAS INTERNATIONAL, INC. | 2002-08-13 | — | — | US | disclosed |
| WO-2001027141-A1 | INHIBITORS OF FACTOR XA HAVING AN ARGININE OR ARGININE ALDEHYDE MIMIC | CORVAS INTERNATIONAL, INC. (US) | 2001-04-19 | — | — | WO | disclosed |
| EP-0204264-B1 | CONVERSION OF URACIL DERIVATIVES TO CYTOSINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1990-08-16 | — | — | EP | disclosed |
| US-4754026-A | Conversion of uracil derivatives to cytosine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-06-28 | — | — | US | disclosed |
| EP-0204264-A2 | Conversion of uracil derivatives to cytosine derivatives | Takeda Chemical Industries, Ltd. (JP) | 1986-12-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293332-A1 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | BDKRB2, BDKRB1, PDXK | ACHE 2052/4885FFAR4 558/4885ALDH1A1 3104/4885 |
| US-20040147519-A1 | Sulfonylquinoxalone acetamide derivatives as bradykinin antagonists | BDKRB2, BDKRB1, HRH2 | ACHE 1914/4885FFAR4 782/4885ALDH1A1 2364/4885 |
| US-20040147520-A1 | Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists | BDKRB2, BDKRB1, PDXK | ACHE 1863/4885FFAR4 632/4885ALDH1A1 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.