Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 5/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28340937 | 0.90 | ACHE (0.48) | RAPGEF4ACHEALDH1A1FFAR4TRPV4 | |
| SCHEMBL7608 | 0.81 | CA1 (0.52) | RAPGEF4ALDH1A1CA1CA2MMP1 | |
| SCHEMBL3231527 | 0.79 | RAPGEF4 (0.45) | RAPGEF4ACHEALDH1A1FFAR4CA1 | |
| SCHEMBL248149 | 0.78 | NMT1 (0.50) | RAPGEF4ACHEF2TRPV4SMN1; SMN2 | |
| SCHEMBL4420745 | 0.78 | ACHE (0.45) | RAPGEF4ACHEALDH1A1FFAR4TRPV4 | |
| SCHEMBL11655127 | 0.76 | EPHX2 (0.43) | ACHEALDH1A1CA1CA2TRPV4 | |
| SCHEMBL10641963 | 0.74 | PKM (0.49) | ALDH1A1FFAR4TRPV4SMN1; SMN2MEN1 | |
| SCHEMBL111919 | 0.74 | ACHE (0.48) | RAPGEF4ACHEALDH1A1FFAR4CA1 | |
| SCHEMBL8062665 | 0.74 | SMN1; SMN2 (0.52) | RAPGEF4ACHEALDH1A1FFAR4CA1 | |
| SCHEMBL2496728 | 0.74 | CYP1A2 (0.47) | ACHEALDH1A1CA1CA2TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115357-A1 | LIVER X RECEPTORS (LXR) MODULATORS | PHENEX-FXR GMBH (DE) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115357-A1 | LIVER X RECEPTORS (LXR) MODULATORS | NR1H2, NR1H3, NR1H4 | RAPGEF4 2631/4885ACHE 4258/4885ALDH1A1 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.