Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924524 | 0.76 | KIF11 (0.47) | KIF11KCNH2KMT2AMEN1LTA4H | |
| SCHEMBL6131386 | 0.76 | KIF11 (0.43) | KIF11KCNH2LMNAHTTSMN1; SMN2 | |
| SCHEMBL16148829 | 0.75 | LMNA (0.38) | KIF11KCNH2LMNASMN1; SMN2 | |
| SCHEMBL16149381 | 0.75 | LMNA (0.38) | KIF11KCNH2LMNASMN1; SMN2 | |
| SCHEMBL28489468 | 0.75 | KIF11 (0.52) | KIF11KCNH2SMN1; SMN2LTA4H | |
| SCHEMBL9752682 | 0.75 | KIF11 (0.42) | KIF11LMNA | |
| SCHEMBL8454432 | 0.75 | KIF11 (0.45) | KIF11KCNH2KMT2ALTA4H | |
| SCHEMBL13388489 | 0.73 | KIF11 (0.50) | KIF11KCNH2 | |
| SCHEMBL20371105 | 0.73 | KIF11 (0.53) | KIF11KCNH2KMT2ALMNAHTT | |
| SCHEMBL7049682 | 0.73 | KIF11 (0.43) | KIF11KCNH2KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081949-A2 | TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | Dharmacon, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-2064223-A2 | DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | Dharmacon, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008036841-A2 | TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036825-A2 | DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2008-03-27 | — | — | WO | disclosed |